Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model

Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis.

BACKGROUND AND PURPOSE Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, ...

Incompletely Evaluated ART Leading to Ectopic Pregnancy and Cerebral Thrombosis

Expression correlates between Annexin A1 and A2 autoantibodies in patients with Behçet’s disease

The autoantibodies profile of Behçet's disease (BD) is yet incompletely understood. Annexins are a family of highly conserved proteins which are involved in some human autoimmune diseases. Autoantibodies directed toward Annexin A1 and A2 are involved in BD pathology, but correlation in their clinical role is controversial. The aim of our study is to estimate and evaluate the expression correlat...

S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.

The defining characteristic of a tumor cell is its ability to escape the constraints imposed by neighboring cells, invade the surrounding tissue and metastasize to distant sites. This invasive property of tumor cells is dependent on activation of proteinases at the cell surface. The serine proteinase plasmin is one of the key proteinases that participate in the pericellular proteolysis associat...

Sudden Bilateral Sensorineural Hearing Loss Secondary to Cerebral Venous Thrombosis

Introduction: Sudden sensorineural hearing loss (SSNHL) is an important otological emergency. Up to 90% of the cases are idiopathic. Cerebral venous thrombosis (CVT) is an extremely rare identifiable cause as it only represents 0.5% of all strokes.   Case Report: In this paper, an unusual case of bilateral SSNHL secondary to bilateral CVT with rapid and complete recovery is reported. The patie...